Hispidulin | MMP-AC0087

	Compound Name :	Hispidulin
	Compound Class :	Flavonoid
	Synonyms :	Hispidulin; Dinatin; 1447-88-7; 4',5,7-Trihydroxy-6-methoxyflavone; Scutellarein 6-methyl ether;
	Compound Extracted from :	Hispidulin is extracted / reported from 4 Plant(s) of Melghat Flora as below MC037: Passiflora foetida L. - fetid passionflower; MH216: Phyla nodiflora (L.) Greene; MH286: Salvia plebeia R.Br.; MT121: Millingtonia hortensis Linn;

	Molecular Formula :	C16H12O6
	Molecular Weight :	300.26
	InChi Key :	IHFBPDAQLQOCBX-UHFFFAOYSA-N
	IUPAC :	5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one
	InChi :	InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
	Hydrogen Bond Donor count :	3
	Hydrogen Bond Acceptor count :	6
	Rotational Bond count :	2
	TPSA :	96.2
	LogP Value :	1.7

	Lipinski Rule of Five :	Yes
	Ghose Filter :	Yes
	Veber Filter :	Yes
	Muegge Filter :	Yes

	PubChem CID :	5281628
	Drugbank ID :	DB14008
	Super Natural :	-
	CTD :	C055957
	HIT :	-
	NCI-60 GI50 data :	1447-88-7

	Reference(s) :	https://www.ncbi.nlm.nih.gov/pubmed/30055130

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0087	U-373	Brain	-	-	8.8 痢/mL	-	10579870
MMP-AC0087	BC-1	Breast	-	-	>20 痢/mL	-	10579870
MMP-AC0087	ZR-75-1	Breast	-	-	1.2 痢/mL	-	10579870
MMP-AC0087	HT	Haematopoietic and Lymphoid tissue	-	-	10.1 痢/mL	-	10579870
MMP-AC0087	LU-1	Lung	-	-	>20 痢/mL	-	10579870
MMP-AC0087	KB	Nasopharyngeal	-	-	18.8 痢/mL	-	10579870
MMP-AC0087	LNCaP	Prostate	-	-	7.1 痢/mL	-	10579870
MMP-AC0087	A-431	Skin	-	-	12.8 痢/mL	-	10579870

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0087	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	1026	Human Glioblastoma Multiforme	GBM8901	40 然	-	-	-	Hispidulin subsequently enhanced the expression level of p21, resulting in cell-cycle arrest in GBM cells.	20734985
MMP-AC0087	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	5564	Human Glioblastoma Multiforme	GBM8901	40 然	-	-	-	AMPK is activated by hispidulin in GBMcells. When this occurs, a key enzyme involved in protein synthesis, mTOR, is inhibited. In addition, the activity and/or expression of lipogenic enzymes, such as FASN and ACC, are decreased.	20734985
MMP-AC0087	TP53	tumor protein p53	7157	Human Glioblastoma Multiforme	GBM8901	40 然	-	-	-	Hispidulin increased the expression level of p53 resulting in cell-cycle arrest in GBM cells.	20734985

MMP-AC0087 : Hispidulin