Eugenol | MMP-AC0139

	Compound Name :	Eugenol
	Compound Class :	Terpenoids
	Synonyms :	eugenol; 97-53-0; 4-Allyl-2-methoxyphenol; 4-Allylguaiacol; Eugenic acid;
	Compound Extracted from :	Eugenol is extracted / reported from 7 Plant(s) of Melghat Flora as below MH073: Cassia tora L.; MH133: Sphaeranthus indicus L.; MS122: Ocimum gratissimum L.; MT013: Aegle marmelos L.; MT017: Chloroxylon swietenia (Roxb.) DC.; MT051: Syzygium cumini (L.) Skeels; MT116: Juglans regia ;

	Molecular Formula :	C10H12O2
	Molecular Weight :	164.2
	InChi Key :	RRAFCDWBNXTKKO-UHFFFAOYSA-N
	IUPAC :	2-methoxy-4-prop-2-enylphenol
	InChi :	InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3,5-7,11H,1,4H2,2H3
	Hydrogen Bond Donor count :	1
	Hydrogen Bond Acceptor count :	2
	Rotational Bond count :	3
	TPSA :	29.5
	LogP Value :	2

	Lipinski Rule of Five :	Yes
	Ghose Filter :	Yes
	Veber Filter :	Yes
	Muegge Filter :	No

	PubChem CID :	3314
	Drugbank ID :	DB09086
	Super Natural :	000093287
	CTD :	D005054
	HIT :	C0416
	NCI-60 GI50 data :	-

	Reference(s) :	https://www.ncbi.nlm.nih.gov/pubmed/28494415

Compound_ID	Cell Lines	Cancer Type	IC50 Value	EC50 Value	ED50 Value	GI50 Value	References
MMP-AC0139	HL-60	Haematopoietic and Lymphoid tissue	93.02 µg/ml	-	-	-	20359874
MMP-AC0139	B16	Skin	163±27 µMol/L	-	-	-	11741740

Compound_ID	Target	Gene_Name	Gene_ID	Cancer	Cell_lines	IC50 Value	EC50 Value	ED50 Value	GI50 Value	Remarks	References
MMP-AC0139	E2F1	E2F transcription factor 1	1869	Melanoma	WM1205Lu	-	-	-	-	cDNA array analysis showed that eugenol caused deregulation of the E2F family of transcription factors. Overexpression of E2F1 restored about 75% of proliferation ability in cultures. These results indicate that deregulation of E2F1 may be a D388key factor in eugenol-mediated melanoma growth inhibition both in vitro and in vivo.	15574415

MMP-AC0139 : Eugenol